Edmund Gehan's Publications

Gehan EA and Freireich, EJ. The 6MP vs Placebo Clinical Trial in Acute Leukemia. Clinical Trials 8(3), 288-297, 2011.

Behrendt CE, Gehan EA. Treatment-subgroup interaction: an example from a published, phase II clinical trial. Contemp Clin Trials. 2009 May;30(3):279-81. Epub 2009 Feb 21.

Gehan, E. Some applications of Bayesian methods in cancer clinical trials. Student (Issue honoruing 80th birthday of Sir David R. Cox), Vol. 5, No. 3, 195-204, 2006.

Gehan E. The future of Biostatistics in Cancer Research. Foundations of Clinical Cancer Research. Vol. 3, 1:24-25, 2005.

Wang, A. and Gehan E. Gene selection for microarray data analysis using principal component analysis. Statistics in Medicine 24:2069-2087, 2005.

Liu, A., Zhang, Y., Gehan, E., Clarke, R. Block principal component analysis with application to gene microarray data classification. Statistics in Medicine 21:3465-3474, 2002.

Gehan, E.A. Role of Biostatistician in Cancer Research. Biomedicine and Pharmacotherapy, 55:502-509, 2001.

Gehan, E.A. Biostatistics in the New Millennium: A Consulting Statistician’s Perspective”. Statistical Methods in Medical Research 9:3-16, 2000.

Schneiderman, M., Gehan, E.A. “Clinical Trials, Early Cancer and Heart Disease” Encyclopedia of Biostatistics, Wiley & Sons, 1:690-698, 1998.

Gehan, E.A. The Scientific Basis of Clinical Trials: Statistical Aspects. Clinical Cancer Research 3:2587-2590, 1997.

Gehan, E.A. and Lemak, N. "Statistics in Medical Research: Developments in Clinical Trials." Plenum Publishing Co., New York, 1994.

Ensign, L.G., Gehan, E.A., Kamen, D.S., and Thall, P.F. "An Optimal Three-stage Design for Phase II Clinical Trials. Statistics in Medicine 13:1727-1736, 1994.

Gehan, E.A., and Schneiderman, M.A. "Historical and methodological developments in early clinical trials at the National Cancer Institute." Stat. in Medicine, 9:871-880, 1990.

Keating, M. J., Gehan, E.A., Smith, T.L., et al. "A strategy for evaluation of new treatments in untreated patients: Application to a clinical trial of AMSA for acute leukemia." Journal of Clinical Oncology, 5:710-721, 1987.

Lawrence, W., Gehan, E.A., Hays, D.M., et al. "Prognostic significance of staging factors of the UICC staging system in childhood rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study (IRS-II)." Journal of Clinical Oncology, 5:46-54, 1987.

Gehan, E.A. and Smith, T.L. "Statistics in oncology: The state of the art Neo-adjuvant Chemotherapy."  Colloque Insrm/John Libbey Eurotext Limited, 137:789-798, 1986.

Gehan, E.A. "The use of prognostic factors in the planning and analysis of cancer clinical trials." IN: Biostatistics: Statistics in the Biomedical, Public Health and Environmental Sciences (The B. G. Greenberg Vol.) P. K. Sen. ed. North Holland Publishers, pp. 39-52, 1985.

Gehan, E.A. The evaluation of therapies: Historical control trials. Statistics in Medicine, 3:315-324, 1984.

Gehan, E.A. and Schneiderman, M. "Experimental design of clinical trials." IN: Cancer Medicine, 2nd ed. J.F. Holland and E. Frei, III, eds. Lea and Febiger: Philadelphia, Pennsylvania, pp. 531-554, 1982.

Gehan, E.A. and Freireich, E.J. "Cancer clinical trials: A rational basis for use of historical controls." Seminars in Oncology, 8:430-436, 1981.

Gehan, E.A. "The training of statisticians for cooperative clinical trials-A working statistician's viewpoint." Biometrics, 36:699-706, 1980.

Gehan, E.A. "Clinical trials in cancer research." Environmental Health Perspectives, 32:31-48, 1979.

Gehan, E.A. "Statistical methods for survival time studies." IN: Cancer Therapy: Prognostic Factors and Criteria of Response. M.J. Staquet, ed. Raven Press: New York, pp. 7-35, 1975 .

Armitage, P. and Gehan, E.A. "Statistical methods for the identification and use of prognostic factors." Internatl. J. of Cancer, 13:16-36, 1974.

Gehan, E.A. and Freireich, E.J. "Nonrandomized controls in cancer clinical trials.” New England J. of Medicine, 290:198-203, 1974.

Gehan, E.A. and Siddiqui, M.M. "Simple regression methods for survival time studies." J. of the Amer. Stat. Assoc., 68:848-856, 1973.

Gehan, E.A. "Estimating survival functions from the life table." J. of Chronic. Diseases 13:629-644, 1969.

Gehan, E.A. "A generalized Wilcoxon test for comparing arbitrarily singly-censored samples." Biometrika, 52:203-225, 1965.

Gehan, E.A. "The determination of the number of patients required in a preliminary and follow-up trial of a new chemotherapeutic agent." J. of Chronic Diseases, 13:346-353, 1961.