Current Bio3 Seminar Series

The Bio3 Seminar Series meets every second and fourth Friday of the month, during the academic year.

*MS and PhD biostatistics students are expected to attend the bi-weekly seminar series, as part of their academic curriculum.*

Seminar Schedule – Fall 2021:

Friday, September 24, 2021 at 10:00 am

Junyi Zhang, M.S.
Biostatistics Ph.D. Candidate, Department of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, DC

Abstract: Group-based trajectory modeling is an increasingly popular methodology for analyzing the developmental trajectories of outcomes over time. This presentation provides an overview of: 1) the statistical foundation of group-based trajectory modeling; 2) the criteria for model selection; 3) the applications of this method in clinical and observational studies; and 4) the extension to two distinct outcomes via dual trajectory modeling. 

Location: Online via Zoom

Friday, September 10, 2021 at 10:00 am

Jared K. Lunceford, Ph.D. 
Distinguished Scientist, Merck Research Laboratories, Early Development Statistics

Abstract: Early or late phase clinical trials that aim to enroll a biomarker selected patient population are often initiated using a clinical trial assay (CTA) which may differ in assay components compared to the final companion diagnostic assay (CDx), potentially necessitating further clinical analysis to bridge study conclusions to results based on the CDx.  There may be substantial missing data due to the retrospective nature of CDx sample testing.  Key elements of the ideas behind bridging will be reviewed using a case study conducted for a randomized trial of pembrolizumab in second line metastatic non-small cell lung cancer.  Emphasis is on methods aimed at constructing an imputation model to (1) confirm the robustness of clinical trial conclusions via the Bayesian posterior predictive distribution of the study’s intention-to-treat testing results and (2) conduct sensitivity analysis for estimands of the intention-to-diagnose population, while capturing all sources of variability. 

Location: Online via Zoom

The Bio3 Seminar Series are for educational purposes and intended for members of the Georgetown University community.  The seminars are closed to the public.