Hongbin Fang’s Publications

Publications in Statistical Journals

  1. Huang, H., Fang, H.B., and Tan, M.T. (2017). Experimental Design for Multi-drug Combination Studies Using Signaling Networks. Biometrics, DOI: 10.1111/biom.12777.
  2. Yang Y, Fang HB, Roy A, and Tan M. (2018). Adaptive oncology phase I trial design of drug combinations with drug-drug interaction modeling. Statistics and Its Interface 11: 109-127.
  3. Wang, S., Yuan, A., Tang, L., Fang, H.B., Tan, M.T., and Chan, L. (2017). ROC analysis for Phase II group sequential basket clinical trial. International Journal of Statistics in Medical Research 6: 22-33.
  4. Zhou W, Yuan A, Thieu T, Fang HB and Tan MT. (2017). Phase II basket group sequential clinical trial with binary responses. Austin Biometrics and Biostatistics 4(1): 1033.
  5. Deng, D., Fang, H.B., Jahromi, K., Song, J. and Tan, M. (2017). Detecting the threshold points for gene expressions under multiple biological conditions. Statistics and Its Interface 10: 643-655.
  6. Wan, W., Pei, X.Y., Grant, S., Birch, J. B., Felthousen, J., Dai, Y., Fang, H.B., Tan, M., and Sun, S. (2017). Nonlinear response surface in the study of interaction analysis of three combination drugs. Biometrical Journal 59: 9-24.  DOI: 10.1002/bimj.201500021.
  7. Fang, H.B., Chen, X., Pei, X. Y., Grant, S. and Tan, M. (2017). Experimental Design and Statistical Analysis for Three-Drug Combination Studies. Statistical Methods in Medical Research 26(3): 1261–1280.  DOI: 10.1177/0962280215574320

  1. Fang, H.B., Huang, H., Clarke, R. and Tan, M. (2016). Predicting multi-drug inhibition interactions based on signaling networks and single drug dose-response information. Journal of Computational Systems Biology, 2(1).
  2. Fang, H.B., Wu, T.T., Rapoport, A. P. and Tan, M. (2016). Survival Analysis with Functional Covariates Based on Partial Follow-up Studies. Statistical Methods in Medical Research 25(6): 2405–2419, Doi: 10.1177/0962280214523586.
  3. Pan, J., Bao, Y., Dai, H. and Fang, H.B. (2014). Joint longitudinal and survival-cure models in tumor xenograft experiments. Statistics in Medicine 33(18): 3229-3240.
  4. Fang, H.B., Deng, D., Zhang, T. and Tan, M. (2014).  Modeling Sustained Treatment Effects in Tumor Xenograft Experiments. Journal of Biopharmaceutical Statistics, 24(4): 755-767.
  5. Fang HB, Deng D, Tian GL, Shen L, Duan K, Song J. (2012). Analysis for temporal gene expressions under multiple biological conditions. Statistics in Biosciences 4(2), 282-299.
  6. Fang HB, Wang J, Deng D, Tang ML. (2011). Estimating the mean of a mark variable under right censoring on the basis of a state function. Computational Statistics and Data Analysis 55, 1726-1735.
  7. Fang HB, Yu T, Tan M. (2010). Efficient experimental design and nonparametric modeling for drug combination. Frontiers in Bioscience E2, 258-265.
  8. Tian GL, Fang HB, Liu Z, Tan M. (2009). Regularized (Bridge) Logistic Regression for Variable Selection Based on ROC Criterion. Statistics and Its Interface 2, 493-502.
  9. Deng D, Fang HB, Sun J. (2009). Nonparametric Estimation for Doubly Censored Failure Time Data. Journal of Nonparametric Statistics 21, 801-814.
  10. Tian GL, Fang HB, Tan M, Qin H, Tang ML. (2009). Uniform distributions in a class of convex polyhedrons with applications to drug combination studies. Journal of Multivariate Analysis 100, 1854-1865.
  11. 7. Deng D, Fang HB. (2009). Asymptotics for nonparametric likelihood estimation with doubly censored multivariate failure times. Journal of Multivariate Analysis 100, 1802-1815.
  12. Fang HB, Tian GL, Li W, Tan M. (2009). Design and sample size for evaluating combinations of drugs of linear and loglinear dose response curves, Journal of Biopharmaceutical Statistics, 19, 625-640.
  13. Tan M, Fang HB, Tian GL. (2009). Dose and sample size determination for multi-drug combination studies. Statistics in Biopharmaceutical Research, 1(3): 301-316.
  14. Zhang W, Fang HB, Song J. (2009). Principle component tests: applied to temporal gene expression data. BMC Bioinformatics, 10(Suppl 1): S26.
  15. Deng D, Fang HB. (2009). On nonparametric maximum likelihood estimations of multivariate distribution function based on interval-censored data. Communications in Statistics-Theory and Methods, 38, 54-74.
  16. Fang HB, Ross DD, Sausville E, Tan M. (2008). Experimental design and interaction analysis of combination studies of drugs with log-linear dose responses. Statistics in Medicine, 27(16):3071-3083.
  17. Tian GL, Tang ML, Fang HB, Tan M. (2008). Efficient methods for estimating constrained parameters with applications to regularized (lasso) logistic regression. Computational Statistics and Data Analysis, 52, 3528-3542.
  18. Tan M, Tian GL, Fang HB, Ng KW. (2007). A fast EM algorithm for quadratic optimization subject to convex constraints. Statistica Sinica, 17(3), 945-964.
  19. Tan M, Tian GL, Fang HB. (2007). An efficient MCEM algorithm for fitting generalized linear mixed models for correlated binary data. Journal of Statistical Computation and Simulation, 77 (11), 929-943.
  20. Fang HB, Tian GL, Xiong X, Tan M. (2006). A Multivariate Random-Effects Model with Restricted Parameters: Application to Assessing Radiation Therapy for Brain Tumors. Statistics in Medicine 25, 1948-1959.
  21. Wang J, Fang HB. (2005). Moments of the Kaplan-Meier estimator under noninformative censoring. Far East Journal of Theoretical Statistics 16, 337-350.
  22. Fang HB, Li G, Sun J. (2005). Maximum likelihood estimation in a semiparametric logistic/proportional-hazards mixture model. Scandinavian Journal of Statistics, 32, 59-75.
  23. Tan M, Fang HB, Tian GL, Houghton PJ. (2005). Repeated-measures models with constrained parameters for incomplete data in tumor xenograft experiments. Statistics in Medicine 24, 109-119.
  24. Tan M, Fang HB, Tian GL, Wei G. (2005). Multivariate normality tests selection for incomplete longitudinal data of small sample sizes, Journal of Multivariate Analysis 93, 164-179.
  25. Fang HB, Tian GL, Tan M. (2004). Hierarchical models for tumor xenograft experiments in drug development. Journal of Biopharmaceutical Statistics 14, 931-945.
  26. Tan M, Fang HB, Tian GL, Houghton, PJ. (2003). Experimental design and sample size determination for drug combination studies based on uniform measures. Statistics in Medicine 22, 2091-2100.
  27. Sun J, Fang HB. (2003). A nonparametric test for panel count data, Biometrika 90, 199-208.
  28. Fang HB, Sun J, Lee MLT. (2002). Nonparametric survival comparisons for interval-censored continuous data, Statistica Sinica 12, 1073-1083.
  29. Tan M, Fang HB, Tian GL, Houghton PJ. (2002). Small-sample inference for incomplete longitudinal data with truncation and censoring in tumor xenograft models, Biometrics 58, 612-620.
  30. Kotz S, Fang HB, Wei G. (2002). Multiple square tray distributions, Statistics & Probability Letters 59, 195-207.
  31. Fang HB, Fang KT, Kotz S. (2002). The meta-elliptical distributions with given marginals, Journal of Multivariate Analysis 82, 1-16.
  32. Fang HB, Sun J. (2001). Consistency of nonparametric maximum likelihood estimation of a distribution based on doubly interval-censored failure time data, Statistics & Probability Letters 53(3), 311-318.
  33. Fang KT, Fang HB, von Rosen D. (2000). A family of bivariate distributions with non-elliptical contours, Communications in Statistics – Theory and Methods 29, 1885-1898.
  34. Liang JJ, Li RZ, Fang HB, Fang KT. (2000). Testing multinormality based on low-dimensional projection, Journal of Statistical Planning and Inference 86, 129-141.

Publications in Medical and Biological Journals

  1. Lin Y, Leng Q, Jiang Z, Guarnera MA, Zhou Y, Chen X, Wang H, Zhou W, Cai L, Fang HB, Li J, Jin H, Wang L, Yi S, Lu W, Evers D, Fowle CB, Su Y, and Jiang F. (2017). A classifier integrating plasma biomarkers and radiological characteristics for distinguishing malignant from benign pulmonary nodules. International Journal of Cancer 141: 1240–1248.  DOI: 10.1002/ijc.30822
  2. Simbulan-Rosenthal CM, Dakshanamurthy S, Gaur A, Chen YS, Fang HB, Abdussamad M, Zhou H, Zapas J, Calvert V,  Petricoin EF, Atkins MB, Byers SW, Rosenthal DS (2017). The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma. Oncotarget 8(8): 12576–12595. DOI: 10.18632/oncotarget.14990
  3. Ma J, Guamera MA, Zhou W, Fang HB, and Jiang F. (2017). A prediction model based on biomarkers and clinical characteristics for detection of lung cancer in pulmonary nodules. Translational Oncology 10(1): 40-45.

  1. Su Y, Guarnera MA, Fang HB, and Jiang F. (2016). Small non-coding RNA biomarkers in sputum for lung cancer diagnosis. Molecular Cancer 15:36.
  2. Cosin JA, Sutherland MAB, Westgate CT, and Fang HB. (2016). Complications of Robotic Gynecologic Surgery in the Severely Morbidly Obese. Annals of Surgical Oncology 23(12): 4035-4041.
  3. Su J, Liao J, Gao L, Shen J, Guarnera MA, Zhan M, Fang HB, Stass SA, and Jiang F. (2015). Analysis of small nucleolar RNAs in sputum for lung cancer diagnosis. Oncotarget 7(5): 5131-5142
  4. Hu R, Warri A, Jin L, Zwart A, Riggins RB, Fang HB, and Clarke R. (2015). NF-κB Signaling is required for XBP1 (Unspliced and Sliced)-Mediated Effects on Antiestrogen Responsiveness and Cell Fate Decisions in Breast Cancer. Molecular and Cellular Biology 35(2): 379-390.
  5. Costello, et al. (2014). A community effort to assess and improve drug sensitivity prediction algorithms. Nature Biotechnology, 32(12): 1202 -1212. As one of NCI-DREAM Community authors, DOI: 10.1038/nbt.2877
  6. Rapoprt AP, Aqui NA, Stadtmauer EA, Vogl DT, Xu YY, Kalos M, Cai L, Fang HB, Weiss BM, Badros A, Yanovich S, Akpek G, Cross A, Mann D, Philip S, Kerr N, Brennan A, Zheng Z, Ruehle K, Milliron T, Strome SE, Salazar AM, Levine BL, and June CH, (2014). Combination immunotherapy after ASCT for multiple myeloma (MM) using MAGE-A3/Poly-ICLC immunizations followed by adoptive cell transfer (ACT) vaccine-primed and costimulated autologous T-Cells. Clinical Cancer Research, 20: 1355-1365.
  7. Li N, Ma J, Guarnera MA, Fang HB, Cai L, and Jiang F. (2014). Digital PCR quantification of miRNAs in sputum for diagnosis of lung cancer. Journal of Cancer Research and Clinical Oncology, 140: 145-150.
  8. Bhatnagar B, Rapoport AP, Fang HB, Ilyas C, Marangoz D, Akbulut V, Ruehle K, Badros A, Yanovich S, and Akpek G, (2014). Single Center Experience with Total-Body Irradiation and Melphalan (TBI-MEL) Myeloablative Conditioning Regimen for Allogeneic Stem Cell Transplantation (SCT) in Patients with Refractory Hematologic Malignancies.Annals of Hematology, 93: 653-660.
  9. Shen J, Liao J, Guarnera MA, Fang HB, Cai L, Stass SA, Jiang F. (2014). Analysis of MicroRNAs in Sputum to Improve Computed Tomography for Lung Cancer Diagnosis. Journal of Thoracic Oncology, 9(1): 33-40.
  10. Hu J, Mondal NK, Sorensen EN, Cai L, Fang HB, Griffith BP, and Wu ZJ, (2014). Platelet glycoprotein Ibα ectodomain shedding and non-surgical bleeding in heart failure patients supported by continuous-flow left ventricular assist devices. Journal of Heart and Lung Transplantation, 33(1): 71-79.
  11. Gojo I, Tan M, Fang HB, Sadowska M, Lapidus R, Baer MR, Carrier F, Beumer JH, Anyang BN, Srivastava RK, Espinoza-Delgado I, Ross DD. (2013). Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia, Clinical Cancer Research, 19:1838-1851.
  12. Hu F, Gartenhaus RB, Zhao XF, Fang HB, Minkove S, Poss DE, apoport AP. (2012). c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphoma. Leukemia Research, in press.
  13. Sen R, Natarajan K, Bhullar J, Shukla S, Fang HB, Cai L, Chen ZS, Ambudkar SV, Baer MR. (2012). The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the multidrug resistance-associated ATP-binding cassette transporter ABCG2. Molecular Cancer Therapeutics 11(9): 2033-2044.
  14. Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros LG, Girnun G. (2011). PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Research, 71(21): 6888-6898.
  15. Ross DD, Shpritz DW, Wolfsthal SD, Zimrin AB, Keay TJ, Fang HB, Schuetz CA, Stapleton LM, Weissman DE. (2011). Creative Solution for Implementation of Experiential, Competency-Based Palliative Care Training for Internal Medicine Residents. Journal of Cancer Education 26: 436-443.
  16. Zhang T, Taskin ME, Fang HB, Jarvik R, Griffith BP, Wu ZJ. (2011). Study of flow-induced hemolysis using novel Couette-type blood shearing Devices. Artificial Organs, 35(12): 1180-1186.
  17. Shen J, Todd NW, Zhang H, Yu L, Xing L, Mei Y, Guarnera M, Liao J, Chou A, Lu CL, Jiang Z, Fang HB, Katz RL, Jiang F. (2011). Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Laboratory Investigation, 91(4): 579-587.
  18. Rapoport AP, Aqui NA, Stadtmauer EA, Vogl DT, Fang HB, Cai L, Janofsky S, Chew A, Storek J, Gorgun Akpek, MD, Ashraf Badros, Yanovich S, Tan M, Veloso E, Pasetti M, Cross A, Philip S, Murphy H, Bhagat R, Zheng Z, Milliron T, Cotte J, Cannon A, Levine BL, Vonderheide RH, June CH. (2011). Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination based on hTERT and survivin after ASCT for myeloma. Blood, 117: 788-797.
  19.  Jiang F, Todd NW, Li R, Zhang H, Fang HB, Stass SA. (2010). A panel of sputum-based genomic marker for early detection of lung cancer. Cancer Prevention Research (Philadelphia), 3(12): 1571-1578.
  20. Hu F, Gartenhaus RB, Eichberg D, Liu Z, Fang HB, Rapoport AP. (2010). PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21. Oncogene 29(40): 5464-5474.
  21. Xing L, Todd NW, Yu L, Fang HB, Jiang F. (2010). Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers. Modern Pathology 23(8), 1157-1164.
  22. Yu L, Todd NW, Xing L, Xie Y, Zhang H, Liu Z, Fang HB, Zhang J, Katz RL, Jiang F. (2010). Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. International Journal of Cancer 127(12), 2870-2878.
  23. Xie Y, Todd NW, Liu Z, Zhan M, Fang HB, Peng H, Alattar M, Deepak J, Stass SA and Jiang F. (2010). Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. Lung Cancer 67(2), 170-176.
  24. Rapoport AP, Stadtamauer EA, Aqui N, Vogl D, Chew A, Fang HB, Janofsky S, Yager K, Veloso E, Zhang Z, Milliron T, Westphal S, Cotte J, Huynh H, Cannon A, Yanovich S, Akpek G, Tan M, Virts K, Ruehle K, Harris C, Philip S, Vonderheide RH, Levine BL, June CH. (2009). Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of costimulated autologous T Cells, Clinical Cancer Research, 15(13), 4499-4507.
  25. Song J, Fang HB, Duan K. (2009). Charactering gene expressions based on their temporal observations. Journal of Biomedicine and Biotechnology, Vol. 2009, Article ID 357937, doi:10.1155/2009/357937.
  26. Shiozawa K, Nakanishi T, Tan M, Fang HB, Wang WC, Edelman MJ, Carlton D, Gojo I, Sausville EA, Ross DD. (2009). Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Combined with Cytosine Arabinoside (ara-C) and Etoposide for Treatment of Acute Leukemias, Clinical Cancer Research, 15(5), 1698-1707.
  27. Vasaitis T, Belosay A, Schayowitz A, Khandelwal A, Chopra P, Gediya LK, Guo Z, Fang HB, Njar VCO, Brodie AMH. (2008). Androgen receptor inactivation contributes to antitumor efficacy of 17-hydroxylase/17,20-lyase inhibitor 3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer, Molecular Cancer Therapeutics, 7(8), 2348-2357.
  28. Yu Y, Zhang H, Tian F, Zhang W, Fang HB, Song J. (2008). An Integrated Epigenetic and Genetic Analysis of DNA Methyltransferase Genes (DNMTs) in Tumor Resistant and Susceptible Chicken Lines, PLoS ONE, 3(7), e2672.
  29. Fan T, Li R, Todd NW, Qiu Q, Fang HB, Wang H, Shen J, Zhao RY, Caraway NP, Katz RL, Stass SA, Jiang F. (2007). Up-regulation of 14-3-3ζ in lung cancer and its implication as prognostic and therapeutic target, Cancer Research, 67(16), 7901-7906.
  30. Hakimian R, Fang HB, Thomas L, Edelman MJ (2007). Lung cancer in HIV-infected patients in the era of highly active antiretroviral therapy, Journal of Thoracic Oncology, 2(4): 268-272.
  31. Li R, Todd NW, Qiu Q, Fan T, Zhao RY, Rodgers WH, Fang HB, Katz RL, Stass SA, Jiang F (2007). Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer, Clinical Cancer Research, 13(2), 482-487.
  32. Qian YB, Zhang JB, Wu WZ, Fang HB, Jia WD, Zhang BH, Pan Q, Xu Y, Wang L, Tang ZY, Sun HC (2006). P48 is a predictive marker for outcome of postoperative interferon-alpha treatment in patients with hepatitis B virus infection-related hepatocellular carcinoma, Cancer, 107(7), 1562-1569.
  33. Rapoport AP, Stadtamauer EA, Aqui N, Badros A, Cotte J, Chrisley L, Veloso E, Zheng Z, Westphal S, Mair R, Chi N, Ratterree B, Pochran MF, Natt S, Hinkle J, Sickles C, Sohal A, Ruehle K, Lynch C, Zhang L, Porter DL, Luger S, Guo C, Fang HB, Blackwelder W, Hankey K, Mann D, Edelman R, Frasch C, Levine B, Cross A, June CH. (2005). Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer, Nature Medicine, 11(11), 1230-1237.
  34. Govorkova EA, Fang HB, Tan M, Webster RG. (2004). Neuraminidase Inhibitor-Rimantadine Combinations Exert Additive and Synergistic Anti-Influenza Virus Effects in MDCK Cells. Antimicrobial Agents and Chemotherapy, 48, 4855-4863.
  35. Cheuk AV, Chin LS, Petit JH, Herman JM, Fang HB, and Regine WF, (2004). Gamma knife surgery for trigeminal neuralgia: outcome, imagine, and brainstem correlates. International Journal Radiation Oncology Biology Physics, 60: 537-541.
  36. Tamburro RF, West NK, Piercy J, Towner G, Fang HB. (2004). Use of the nursing acuity score in children admitted to a pediatric oncology intensive care unit. Pediatric Critical Care Medicine 5(1): 35-39.
  37. Nakanishi T, Doyle LA, Hassel B, Wei Y, Bauer KS, Wu S, Pumplin DW, Fang HB, Ross DD. (2003). Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of xenopus laevis, Molecular Pharmacology 64: 1452-1462.

  1. Tan, M., Fang, H.B., Huang, H. and Yang, Y. (2016). Design and Statistical Analysis of Multidrug Combinations in Preclinical Studies and Clinical Trials. In Statistical Applications from Clinical Trials and Personalized Medicine to Finance and Business Analytics (Lin, J., Wang, B., Hu, X., Chen, K., Liu, R. eds.), pp. 215-234, Springer, New York & Switzerland.
  2. Tan M, Fang HB. (2008). Advanced Statistical Methods for the Design and Analysis of Tumor Xenograft Experiments. In Handbook of Cancer Models with Applications (W.Y. Tan and L. Hanin eds.), pp. 501-520, World Scientific publishing Co., New York.
  3. Fang HB, Kotz S, Wei G. (2005). Dependence patterns of random variables: geometric properties of copulas, In Contemporary Multivariate Analysis and Experimental Designs (J. Fan and G. Li eds.), pp. 121-140, World Scientific Publishing Co. Inc., Singapore.
  4. Tan M, Fang HB, Tian GL. (2005). Statistical analysis for tumor xenograft experiments in drug development, In Contemporary Multivariate Analysis and Experimental Designs (J. Fan and G. Li eds.), pp. 351-368, World Scientific Publishing Co. Inc., Singapore.
  5. Tan M, Tian GL, Fang HB. (2003). Estimating restricted normal means using the EM-type algorithms and IBF sampling, In Development of Modern Statistics and Related Topics (J. Huang and H. Zhang eds.), pp. 53-73, World Scientific Publishing Co. Inc., Singapore.
  6. von Rosen D, Fang HB, Fang KT. (1997). An extension of the complex normal distribution, in Advances in the Theory and Practice of Statistics: A Volume in Honor of Samuel Kotz, (ed. by N.L. Johnson and N. Balakrishnan), 415-427, John Wiley Sons, Inc.

  1. Teng CY, Fang HB, Yang J. (1993). The exact distribution of IV estimators of exogenous variable coefficients with a certain kind of nonnormal disturbance in the simultaneous equations, Northeast. Math. J. 9(2), 157-163.
  2. Teng CY, Chen TH, Fang HB. (1990). The exact distribution of the estimator of parameters in the SUR model, Acta Sci. Natur. Univ. Sunyatseni, 29(3), 31-36.
  3. Yang J, Chen TH, Fang HB. (1989). Distribution of latent roots of random matrix-rations for families of elliptically contoured distributions (in Chinese), Acta Sci. Natur. Univ. Sunyatseni, 28(4), 43-48.
  4. Teng CY, Fang HB, Deng WC. (1989). The generalized noncentral Wishart distribution, J. Math. Res. Exposition, 9(4), 479-488.
  5. Yang XY, Fang HB. (1987). Bound law of the iterated logarithm for a sequence of independent B-valued random variables (in Chinese), Chinese J. Appl. Probab. Statist. 3(2), 113-121.