Edmund Gehan’s Publications

  1. Gehan, E.A. (2017) Memoir of a Number Doctor, Gorham Co, Centralia , Washington
  2. Gehan EA and Freireich, EJ. The 6MP vs Placebo Clinical Trial in Acute LeukemiaClinical Trials 8(3), 288-297, 2011.
  3. Behrendt CE, Gehan EATreatment-subgroup interaction: an example from a published, phase II clinical trialContemp Clin Trials. 2009 May;30(3):279-81. Epub 2009 Feb 21.
  4. Gehan, E. Some applications of Bayesian methods in cancer clinical trials. Student (Issue honoruing 80th birthday of Sir David R. Cox), Vol. 5, No. 3, 195-204, 2006.
  5. Gehan E. The future of Biostatistics in Cancer Research. Foundations of Clinical Cancer Research. Vol. 3, 1:24-25, 2005.
  6. Wang, A. and Gehan E. Gene selection for microarray data analysis using principal component analysis. Statistics in Medicine 24:2069-2087, 2005.
  7. Liu, A., Zhang, Y., Gehan, E., Clarke, R. Block principal component analysis with application to gene microarray data classification. Statistics in Medicine 21:3465-3474, 2002.
  8. Gehan, E.A. Role of Biostatistician in Cancer Research. Biomedicine and Pharmacotherapy, 55:502-509, 2001.
  9. Gehan, E.A. Biostatistics in the New Millennium: A Consulting Statistician’s Perspective”. Statistical Methods in Medical Research 9:3-16, 2000.
  10. Schneiderman, M., Gehan, E.A. “Clinical Trials, Early Cancer and Heart Disease” Encyclopedia of Biostatistics, Wiley & Sons, 1:690-698, 1998.

  1. Gehan, E.A. The Scientific Basis of Clinical Trials: Statistical Aspects. Clinical Cancer Research 3:2587-2590, 1997.
  2. Gehan, E.A. and Lemak, N. “Statistics in Medical Research: Developments in Clinical Trials.” Plenum Publishing Co., New York, 1994.
  3. Ensign, L.G., Gehan, E.A., Kamen, D.S., and Thall, P.F. “An Optimal Three-stage Design for Phase II Clinical Trials.Statistics in Medicine 13:1727-1736, 1994.
  4. Gehan, E.A., and Schneiderman, M.A. “Historical and methodological developments in early clinical trials at the National Cancer Institute.” Stat. in Medicine, 9:871-880, 1990.
  5. Keating, M. J., Gehan, E.A., Smith, T.L., et al. “A strategy for evaluation of new treatments in untreated patients: Application to a clinical trial of AMSA for acute leukemia.” Journal of Clinical Oncology, 5:710-721, 1987.
  6. Lawrence, W., Gehan, E.A., Hays, D.M., et al. “Prognostic significance of staging factors of the UICC staging system in childhood rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study (IRS-II).” Journal of Clinical Oncology, 5:46-54, 1987.
  7. Gehan, E.A. and Smith, T.L. “Statistics in oncology: The state of the art Neo-adjuvant Chemotherapy.”  Colloque Insrm/John Libbey Eurotext Limited, 137:789-798, 1986.
  8. Gehan, E.A. “The use of prognostic factors in the planning and analysis of cancer clinical trials.” IN: Biostatistics: Statistics in the Biomedical, Public Health and Environmental Sciences (The B. G. Greenberg Vol.) P. K. Sen. ed. North Holland Publishers, pp. 39-52, 1985.
  9. Gehan, E.A. The evaluation of therapies: Historical control trials. Statistics in Medicine, 3:315-324, 1984.
  10. Gehan, E.A. and Schneiderman, M. “Experimental design of clinical trials.” IN: Cancer Medicine, 2nd ed. J.F. Holland and E. Frei, III, eds. Lea and Febiger: Philadelphia, Pennsylvania, pp. 531-554, 1982.
  11. Gehan, E.A. and Freireich, E.J. “Cancer clinical trials: A rational basis for use of historical controls.” Seminars in Oncology, 8:430-436, 1981.
  12. Gehan, E.A. “The training of statisticians for cooperative clinical trials-A working statistician’s viewpoint.”Biometrics, 36:699-706, 1980.
  13. Gehan, E.A. “Clinical trials in cancer research.” Environmental Health Perspectives, 32:31-48, 1979.
  14. Gehan, E.A. “Statistical methods for survival time studies.” IN: Cancer Therapy: Prognostic Factors and Criteria of Response. M.J. Staquet, ed. Raven Press: New York, pp. 7-35, 1975 .
  15. Armitage, P. and Gehan, E.A. “Statistical methods for the identification and use of prognostic factors.” Internatl. J. of Cancer, 13:16-36, 1974.
  16. Gehan, E.A. and Freireich, E.J. “Nonrandomized controls in cancer clinical trials.” New England J. of Medicine, 290:198-203, 1974.
  17. Gehan, E.A. and Siddiqui, M.M. “Simple regression methods for survival time studies.” J. of the Amer. Stat. Assoc., 68:848-856, 1973.
  18. Gehan, E.A. “Estimating survival functions from the life table.” J. of Chronic. Diseases 13:629-644, 1969.
  19. Gehan, E.A. “A generalized Wilcoxon test for comparing arbitrarily singly-censored samples.” Biometrika, 52:203-225, 1965.
  20. Gehan, E.A. “The determination of the number of patients required in a preliminary and follow-up trial of a new chemotherapeutic agent.” J. of Chronic Diseases, 13:346-353, 1961.